6/14/2023 0 Comments Bimx lab![]() ![]() aeruginosa strains, which are the first to colonize CF patients. Our studies have indicated that although alginate is a key biofilm matrix component of mucoid strains, it’s not a significant component of the matrix of nonmucoid P. For some time, alginate has been considered the major polysaccharide of the biofilm EPS matrix. Biofilm bacteria produce one or more extracellular polymeric substances (EPS) that act as a scaffold, holding biofilm cells together and to a surface. ![]() We are also interested in the impact of host protein matrix interactions and their ability to impact biofilm survival and pathogenicity.Ī critical element of Pseudomonas aeruginosa pathogenesis is its ability to form biofilms in the lungs of CF patients. aeruginosa and the function they play for the biofilm community. Our lab is focused on identifying specific biofilm matrix proteins of P. Outside of matrix proteins that provide structural functions, we predict that matrix associated proteins can play both nutritional and protective roles for the community. We have additionally identified a novel matrix integrity protein, a Psl-binding lectin, LecB. CdrA provides structural integrity through extracellular interactions with the matrix polysaccharide Psl. Our groups identified a biofilm matrix protein for P. However, the protein component of the biofilm matrix has been relatively understudied. ![]() The regulation of matrix production and the carbohydrate component of the matrix have both been examined. Pseudomonas aeruginosa represents a paradigm species for the study of biofilms in the laboratory. Biofilms produce an extracellular matrix that functions, in part, to hold the community together. Thus, significant research has been directed towards understanding the basic biology behind biofilm formation. Our lab is currently focused on these areas:īiofilm formation has been linked to many chronic bacterial infections. ![]()
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